Table V OVs - OncoLyticVirus.org

Table V- Targeting with “tumor-selective” infection.

Virus	Redirected viral ligand	Cellular target	Effect	References
Dual Adenovirus system^A: AdsCAR-EGF + D24	Bispecific- antibody binding adenovirus fiber to EGFR	EGFR	Redirects viral infection to EGFR-expressing cells	(32)
Adenovirus: Ad5-D24RGD	H1-loop in Fiber of Ad modified by incorporation of RGD	Integrin	Redirects viral infection to integrin-expressing cells.	(33)
D24or ONYX-015^B	Infusion of bispecific antibodies to fiber and EGFR	EGFR	Redirects viral infection to EGFR-expressing cells	(34)
Ad 5/35	Fiber of adenovirus serotype 35 substituted into adenovirus serotype 5	Unknown	Redirects viral infection away from CAR and towards an unidentified cellular receptor present in human breast cancer	(35)

^A Consists of a 1:1 mix of replication-defective, sCAR-EGFR secreting adenovirus and the OV, AdD24 (Table 4). ^BDiscussed in more detail in Table 5.

Disclaimer About Medical Information:The information and reference materials contained herein is intended solely for the information of the reader. It should not be used for treatment purposes, but rather for discussion with the patient's own physician.

	All Rights Reserved. Copyright © 2004 E.A. Chiooca, MD Last modified: Thursday, April 20, 2006 5:04 PM . Site Issues Contact: