Virus (Company, if known)

Tumor-specific Promoter

Viral gene

Effect

References

Adenovirus CV706 (Calydon, Inc.)

PSA (prostate)

E1A

Replication restricted to prostate tissue

(24)

Adenovirus CN787 (Calydon, Inc.)

a)Rat probasin promoter for E1A

b) PSA for E1B

E1A and E1B

Same as above

(25, 26)

Adenovirus CV980 (Calydon, Inc.)

AFP (hepatocellular carcinoma)

E1A and E1B

Replication restricted to hepatic tumors.

(27)

Adenovirus ONYX-411 (Onyx Pharmaceuticals)^A

E2F1 promoter (most tumors)

E1A and E4

Increased dependence of virus replication on overactive E2F

(13)

Adenovirus 01/PEME (Canji Inc.)^B

p53 promoter (most tumors)

E2F antagonist.

Expression of E2 and subsequent viral genes dependent on loss of p53 function

(22)

CG8840 (Cell Genesys, Inc.)

Uroplakin II (bladder)

E1A and E1B

Replication restricted to bladder cancer

(28)

KD1-SPB

Surfactant protein B

E4

Replication improved in lung tumors

(29)

HSV Myb34.5 (Prestwick Scientific, Inc.)^A

B-Myb promoter (most tumors)

g34.5 (ICP34.5)

Improved replication in tumors

(16, 17)

HSV DF3g34.5

DF3 promoter

g34.5 (ICP34.5)

Improved replication in MUC1-positive pancreatic and breast tumor cells.

(30)

HSV G92A

Albumin promoter

ICP4

Replication restricted in hepatoma

(31)