Virus (Company, if known)

Mutated viral gene

Cellular target

Effect

References

Adenovirus ONYX-015  (Onyx Pharmaceuticals)

E1B-55Kd

p53

Viral replication restricted to p53-defective mutants

(20)

Adenovirus 01/PEME (Canji)

1)       p53 promoter driving expression of E2F antagonist

2)       E1A-CR1 p300 binding-domain

3)       E3 deletion

4)       Extra Major Late Promoter driving expression of E3-11.6 Kd

p53, p300.

Expression of E2 and subsequent viral genes dependent on loss of p53 function; wild-type p53 function enhanced by p300 coactivation; increased adenoviral release and cell death by  adenoviral death protein (21)

(22)

AAV

AAV unusual DNA structure is precipitating factor

p53/ p21

Lack of G2/M arrest in p53-defective cells, infected with AAV, causes cell death

(23)