Virus (Company, if known)

Mutated viral gene

Cellular target

Effect

References

Adenovirus D24  and dl922-947 (Onyx Pharmaceuticals)

E1A-CR2 domain

PRB

Viral replication restricted to pRB-defective mutants

(10, 11)

Adenovirus CB106

E1A-CR1 and CR2 domains

PRB, p300, p107, p130

In keratinocytes, viral replication restricted to papillomavirus E6/E7 expressors

(12)

Adenovirus ONYX-411(Onyx Pharmaceuticals)

a)       E1A-CR1

b)       E2F promoter driving E1A and E4 genes

c)       E3 deletion

PRB and upregulated E2F transcription factor

Increased dependence of virus replication on overactive E2F

(13)

HSV: hrR3, rRp450, HSV1yCD, MGH1, G207 (Medigene, Inc.), G47D)

Ul39 (ICP6)

RR activity elevating dNTP pools

Viral replication depends on dNTP pools

(14, 15)

HSV Myb34.5 (Prestwick Scientific, Inc.)

a)       UL39 (ICP6)

b)       B-Myb (E2F-responsive) promoter driving g34.5 gene)

RR activity elevating dNTP pools and upregulated E2F transcription factor

Increased viral replicative dependence on E2F activity

(16, 17)

Vaccinia  vvDD-GFP

TK gene

Elevated dTTP (due to cellular TK?)

Viral replication restricted to cells with dTTP pools

(18, 19)