Virus (Company, if known)

Viral gene defect

Cellular Target

Tumor models

References

Influenza A

NS1

PKR

Melanoma

(1)

HSV1mutants: R3616, 1716, G207 (Medigene, Inc.), MGH1

ICP34.5

Protein phosphatase 1a, Defective interferon signaling.

Brain, Colorectal, ovarian, lung, prostate, breast

(2, 3)

Reovirus (Oncolytics Biotech., Inc.)

None

Overactive Ras pathway

Brain, ovarian, breast, colorectal

(4-7) .

VSV

None

Defective Interferon signaling

Melanoma

(8)

Newcastle disease virus (Provirus)

None

Overactive Ras pathway

Fibrosarcoma, Neuroblastoma

(9)